CSIR-NCL has developed a cost-e?ective and sustainable catalytic process for the manufacturing of Para-Aminophenol (PAP) — a critical intermediate for Paracetamol (Acetaminophen) production. India currently imports approximately 25,000 TPA of PAP, with 70–80% sourced from China. To become self-reliant there is a strong need to adopt indigenous technologies. Our developed process o?ers an improved alternative to the existing PNCB route, addressing several process-related challenges. The technology is demonstrated successfully at 0.5 kg/PAP batch scale and TRL 4. This process is now available for licensing and co-development.
प्रौद्योगिकी प्रस्ताव
CSIR-NCL’s
novel catalytic process for PAP is available for licensing and co-development:
•Recyclable non-noble metal catalyst
•Demonstration scale: 0.5
kg/PAP batch
•Complete conversion of PNCB to PAP
•Yield: 85 to 90%
•Purity: 95-97 %
•Organic solvent free process
अनुप्रयोग
KSM for production Paracetamol
मूल्य प्रस्ताव
•Improved
& Cost-effective process
•Inexpensive
non-noble metal
catalyst
•100% conversion
of PNCB to PAP
•Green
process (Organic solvent free process)
•Higher
productivity as compared to the conventional process
•Reduced
water footprint
(Significant reduction in effluent generation compared to the commercial
process)
•Patent
protected technology
बाज़ार संभाव्यता
•157,000 TPA (2023) worldwide demand
•$620.6 M global PAP market size (2024)
•Expected to grow at 6.1% CAGR to $1.05 billion by 2034
•India imports of PAP 21000-25000 TPA & 70-80% is from China
पृष्ठभूमि
• PAP is the key starting material (KSM) for the production of paracetamol
• Existing PNCB process is associated with several drawbacks viz. generation of considerable alkaline effluent wastewater, less throughput, high utility requirement, use of expensive noble catalyst, PAP quality issues, etc.
• Our improved technology addresses the above mentioned challenges; offering cost-effective and viable alternative
